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  • Scientists Gave a Mouse a Stretch of Human DNA and Its Brain Grew 6% Bigger

    Scientists Gave a Mouse a Stretch of Human DNA and Its Brain Grew 6% Bigger

    A team of scientists at Duke University made a mouse just a bit more human.

    They didn’t give it speech or opposable thumbs. They gave it something much smaller — a tiny stretch of human DNA known as HARE5. And in return, the mouse grew a brain about 6.5% bigger than its peers.

    The tweak was minuscule. But the effect — a thickened outer cortex teeming with new neurons — could help explain one of the biggest mysteries in evolution: how our ancestors’ brains tripled in size after diverging from chimpanzees millions of years ago.

    “We still do not have a definitive answer to how the human brain has tripled in size since our split from chimpanzees,” said Gabriel Santpere Baró, a neuroscientist at the Hospital del Mar Medical Research Institute in Spain. This study, apparently, gets us closer to understanding.

    The study confirmed only a brain size enhancement, not necessarily a cognitive one as well. Further research on this subject is underway. Image generated using Sora/ChatGPT

    A Human Brain Accelerator

    The study, published in Nature, dives into a small but powerful group of DNA sequences known as Human Accelerated Regions, or HARs. These segments are nearly identical in all mammals — except us. In humans, they’ve rapidly mutated since we branched off from our primate relatives.

    Most HARs don’t code for proteins. Instead, they serve as enhancers — switches that dial nearby genes up or down. Scientists have long suspected that HARs are part of the recipe that makes human brains so big and intricate, but proving that has been difficult.

    The team, led by developmental neurobiologist Debra Silver, focused on one particular enhancer: HARE5, which boosts a gene called Frizzled8, or Fzd8, known to play a role in early brain development.

    Silver had identified HARE5 over a decade ago. But now, using an arsenal of tools — including genetically edited mice, chimpanzee and human brain organoids, and single-cell RNA sequencing — her team has mapped out in detail how this enhancer helps build a bigger brain.

    “The story is much more complete and convincing,” said Katherine Pollard, a bioinformatician at the Gladstone Institutes who first coined the term HARs in 2006.

    When the researchers replaced the mouse version of HARE5 with the human version, they watched the mice’s brains grow — not just in size, but in complexity. Under the microscope, the brains revealed more radial glia, a type of neural stem cell that multiplies early in development and gives rise to neurons.

    These humanized mice produced more excitatory neurons and displayed greater functional independence between brain regions, suggesting not just more cells, but more refined circuitry.

    Organoids and Origins

    To test whether the findings held beyond mice, the team grew 3D miniature brain models — or organoids — from human and chimpanzee stem cells. When they inserted human HARE5 into chimpanzee cells, they observed the same pattern: increased radial glial proliferation and faster maturation.

    Looking closer, the researchers pinpointed four mutations unique to the human HARE5. Each of these genetic changes — absent in chimpanzees — acted like a volume knob, turning up enhancer activity. Together, they dialed up the WNT signaling pathway, a cascade of molecular messages crucial for neural growth.

    “These findings illustrate how small changes in regulatory DNA can directly affect critical signalling pathways to modulate brain development,” the authors wrote.

    Still, it’s not yet clear whether those larger mouse brains make for smarter mice but tests are underway.

    Building the Big Picture

    HARE5 is just one of over 3,000 HARs scattered across the human genome. Each may contribute a small piece to the puzzle of human brain evolution. Together, they likely interact in complex ways — amplifying, dampening, or redirecting one another.

    “They still represent a genetic treasure trove that we must keep digging into,” said Santpere Baró.

    Silver’s lab is now developing new methods to study how these HARs function together. It’s possible that entire networks of enhancers, each subtly shaping the growth and wiring of the cortex, formed the genetic scaffolding that allowed humans to outsmart every other species.

    In a sense, our brains may be the sum of tiny tweaks — not to the genes themselves, but to the instructions that control them.

    It’s not evolution by brute force, but by fine-tuning.

    “There are many, many different mechanisms that are critical to making the human brain what it is,” Silver said.

  • Our 5 Best Theories About OpenAI and Jony Ive’s Mysterious AI Gadget

    Our 5 Best Theories About OpenAI and Jony Ive’s Mysterious AI Gadget

     

    AI gadgets are back, baby! Or that’s what Jony Ive and Sam Altman hope. Well, they may not really hope they’re back as much as they hope they’re not completely and utterly cooked. ICYMI, Ive and OpenAI’s CEO, Sam Altman, announced in a post-Google I/O keynote bombshell that they are teaming up under a new company called, “io” to make, um… something? Whatever it is, it’s apparently worth $6.5 billion of OpenAI’s cold, hard AI revolution money.

    We truly, genuinely, do not know what the two are making together outside of the fact that it’s going to be a piece of hardware (or potentially many), and it will be centered on AI (duh). But just because we can’t answer the burning question of what this thing is yet doesn’t mean we don’t have some clues. For your speculative pleasure, I’ve gone ahead and aggregated the best hints we have so far, Pepe Silvia-style, to bring us at least one baby step closer to hazarding a guess. Here are the tastiest “phone-killing” AI gadget rumors we have so far.

    Lots of the best hints about what we can expect come from a Wall Street Journal report published on Wednesday. According to the report, Altman gave the OpenAI staff a preview of devices in the pipeline and offered a little insight into what they may be like.

    Two key elements, according to the WSJ report, are that the gadget will be “fully aware” of a user’s “surroundings and life.” That obviously doesn’t offer a ton in terms of what shape the form factor will take, but it does point toward the ultimate product having sensors—a camera, microphone, maybe some sort of computer vision? Again, it’s hard to say, but to be “aware,” the AI device is going to need some of that stuff. And that’s not just me guessing on that front…

    Another detail from WSJ is that the gadget will be “unobtrusive,” which could refer, at least in part, to Ive’s trademark minimalist aesthetic, but likely hints at a more key aspect of its design—no screen. The screenless aspect seems to be corroborated by an inside scoop from Ming-Chi Kuo, a longtime technology analyst and credible tech rumor source. In a post on X, Kuo writes, “It will have cameras and microphones for environmental detection, with no display functionality.”

    That’s not surprising given that Ive has gone on record previously talking about how he doesn’t exactly love what the iPhone has become since he helped pioneer it with Steve Jobs back in the day. Whether a screenless AI device can actually succeed where others like Humane’s Ai Pin failed is a big question, but Ive and Altman seem to be willing to give the idea another go.

    One of the strangest details that hit me while sorting through the drip is how Altman is referring to the duo’s hardware. According to WSJ, Altman referred to the device as a “companion.” That could really mean anything, but to me, when I see “companion,” my mind gravitates less to a wearable and more to… a robot? I’m not the only one looking in that direction, either. Altman has at least given some indication in the past that he wants to make a “really cute” computer, and this would seem to be a perfect opportunity to do just that.

    Another interesting bit from Kuo’s “industry research” is that the device may ultimately not compute entirely on its own. Kuo writes that “it is expected to connect to smartphones and PCs, utilizing their computing and display capabilities.” If you ask me, that’s a bit of a cop-out in terms of being screenless and nowhere near as quirky as the Humane AI Pin’s projection interface, but probably a smart idea in the long term for making something that’s, uh, functional. There’s a lot we can guess at with this nugget, but my brain skates to some kind of agentic AI—think a connective “companion” that you carry around to do computer stuff for you. A thing that connects to the thing to make things less annoying! Sounds convoluted but potentially useful?

    One of the most confusing bits of messaging is on the wearable front. Making an AI wearable has proved difficult, if the Ai Pin is any indication, but according to Kuo, there could be a wearable aspect to it. “One of the intended use cases is wearing the device around the neck,” writes Kuo. That seems to contradict some of the initial rumblings from the WSJ, however. According to the WSJ, the device will be “able to rest in one’s pocket or on one’s desk, and would be a third core device a person would put on their desk after a MacBook Pro and an iPhone.”

    Pocket and desk? That doesn’t really sound wearable-esque to me, but I guess the answer could be somewhere in between. There are already some AI devices out there—like this AI pendant—that are intended to be worn around your neck, so the idea wouldn’t be totally novel, but something tells me Ive and Altman are looking to iterate on existing form factors for AI gadgets. And wearables? So passé.

  • 10 Mind-Blowing Discoveries for Life on Mars

    10 Mind-Blowing Discoveries for Life on Mars

    The discovery of extraterrestrial life would be the greatest scientific achievement in history. While lots of science and technology exist that’s crazier in technical terms, finding life has the grandest existential implications.

    Right now, the best place to find it is Mars. In fact, there are plenty of intriguing life signs and promising environments for past or even present life forms. One idea presents the possibility that we’ve even already discovered and killed Martian organisms, way back in the 1970s. Overall, we should be appreciative, if not massively excited, that the discovery of alien life could happen, well, tomorrow. And if life exists on Mars, it must exist in many other places, including on some planets or moons where it may have become intelligent and formed civilizations.

    So let’s thank Mars for the mind-blowing existential implications proffered by the discoveries below.

    Related: Top 10 Bizarre And Deadly Exoplanets

    10 Life Could Currently Exist on the Surface of Mars

    Most scenarios include finding the signs of ancient life, like chemicals or a nice fossil in a rock. But there’s a possibility that life exists on Mars today, and not deep within a cave or somewhere inaccessible.

    Instead, life could be thriving in pockets of meltwater on the surface of Mars. On Earth, similar meltwater pools are full of living things, including fungi and cyanobacteria.

    Mars’ water ice fell as snow millions of years ago, mixed with dust. The snow solidified into dusty ice, and the dust grains absorb heat because they’re darker. This heat melts a bit of water a few feet under the surface of the ice, potentially creating a habitable environment. Additionally, enough sunlight penetrates to allow photosynthesis to occur down to a depth of 10 feet (3 meters) below the ice.[1]

    9 Maybe We Found Martian Life and Accidentally Killed It

    We’ve been exploring Mars for over 50 years, courtesy of the Viking landers launched in the mid-1970s. These landers performed some very tantalizing life detection experiments… that came up positive! Well, some of them did, but not all. Though confusing and intriguing, the consensus was that no life had been discovered.

    But another possible scenario is much more mind-blowing and depressing: We did discover life and promptly killed it. As a result, some tests showed a negative. It makes theoretical sense, as any organisms on Mars would be adapted to a very dry way of life.

    Since the Viking landers performed experiments that added water to the desiccated Martian dirt, this may have drowned any dry-adapted organisms that may have been present.

    Additionally, the experiments heated up a Martian sample to check for organic compounds, which again could have killed certain organisms that may have just been minding their own business until we came along. Ultimately, our future searches for Martian life must also ensure we don’t accidentally kill it.[2]

    8 Mars Was a Habitable “Vacation-Style” Paradise

    Mars wasn’t just habitable but a prime vacation spot akin to Earth’s beach-iest paradises. Unfortunately for future spacefarers, Mars’ idyllic beach-beauty is several billion years in the past.

    So says China’s Zhurong Mars rover, which had a short but fruitful life because it revealed our red neighbor’s ancient shorelines, sandy beaches, and lapping waves. In its one year of operation, Zhurong (named after the Chinese god of fire) traveled 1.2 miles (1.9 km) to detect underground beach deposits at the site of a long-gone ocean.

    The new information helps paint a stunning Martian picture, showing the red planet with a massive ocean that still covered half its surface about 3.6 billion years ago. With waves and rivers carrying sediments, many materials mixed and bolstered the odds of Martian life.[3]

    7 Mars Has Enough Underground Water to Cover Its Entire Surface

    Even though Mars once had beach-y ocean idylls long ago, it’s still apparently a very wet planet… below the surface. In terms of being available, this hidden water is not; it’s locked away underground, too deep to tap.

    So says recent research using seismic waves (created by “Mars-quakes”) to analyze the red planet’s interior. The amount of water in the Martian interior is actually mind-boggling. Our red neighbor hides enough water to fill its empty, ancient oceans. It has enough water to cover the entire planet to a depth of about one mile (1.6 km).

    Sadly, if you’re picturing a Journey to the Center of the Earth-style ocean, that’s not the case. The water resides within tiny rocky pores and cracks in the middle of the planet’s crust, at depths of 7 to 13 miles (11 to 21 km). Excitingly, if life existed on Mars, it could still be extant, feeding off this hidden water and protected from the harsh, airless surface.[4]

    6 Scientists May Have Already Detected the Signs of Life on Mars

    In the search for life on Mars, multiple mind-boggling scenarios exist. Including the scenario in which we’ve ALREADY detected life on Mars. This comes courtesy of NASA’s Perseverance, who (yes, we should consider it a person) found tantalizing “leopard spots” and “poppy seeds” on the red planet last year.

    These things are suggestive of past Martian life, say multiple scientists. The leopard spots are just 0.04 inches (1 mm) in size, and the poppy seeds among them are even smaller. These dots, basically, are found in an ancient riverbed called Neretva Vallis.

    This is one of the places where scientists were most hopeful of finding life, even before this leopard-y discovery. Plus, it doesn’t look like the features were created by abiotic (non-life) processes involving heat.

    Finally, combined with the fact that analogous features on Earth are kickstarted by microbes, let’s keep our fingers crossed that this could herald the greatest scientific discovery yet.[5]

    5 Perseverance Paints Pictures of a Warm, Wet, and Weird Mars

    Some of the best discoveries happen accidentally or on a whim. Recently, Purdue professor and Mars expert Roger Wiens had the Perseverance rover shoot its laser at an oddly pale Martian rock—no, it wasn’t the type of sci-fi laser that shoots down Tie Fighters, but an exploratory science-advancing type of laser. The laser-assisted evidence points to a “warmer, wetter, and weirder” Mars than expected.

    The rock had lots of aluminum associated with kaolinite. Kaolinite is a mineral that usually forms in very life-friendly environments, like in warm, rainy places or around hot springs and other hydrothermal areas.[6]

    4 Let’s Look for Fat

    We may be looking for the wrong signs of life; instead of looking for proteins, let’s look for fat! So says Georgetown geochemist Anais Roussel because amino acids aren’t great markers of life. They can form without life and are present in places like meteorites.

    However, the lipid (fat) molecules found in cell membranes (a cell’s barrier) are a better indicator since they signal life. However, there’s a problem. Mars lost its protective atmosphere four billion years ago and has been bombarded by the heavy radiation from supernovas.

    Sadly, it’s likely that these billions of years of supernova bombardment would have degraded any fatty life signs at the surface of Mars. To find Martian fossils, we may have to dig really deep below the red surface.[7]

    3 Gale Crater (Lake) Would Have Been a Tourist Hotspot

    The solar system is full of the wonders of the past, present, and future. One of the planet’s hottest tourist attractions (for any time-traveling spacefarers) would have been Gale Crater, the 95-mile (153-km) wide basin just south of the Martian equator.

    Long ago, Gale Crater was a lake. And while it’s evident at a glance that cosmic climate change turned it into a barren desert, scientists now say that its water lasted far longer than anyone believed. How can anyone detect water stretching back to four billion years ago?

    It affected other parts of the landscape, namely the sandstone rock. More interesting still, researchers aren’t sure exactly what type of water it was. It may have been brine, slush, or pressurized liquid, each with its own implications for life. Salt water, for example, has a lower freezing point than non-salt water.

    Some say that Mars’ water was basically vaporized around four billion years ago—since the protective magnetic field and atmosphere disappeared. Yet it’s possible the water remained much longer. Perhaps it didn’t vanish until the late Hesperian, the age of Mars that lasted from 3.7 to 2.9 billion years ago, boosting the odds for biology emerging on our red neighbor.[8]

    2 Mars Was a “Planet of Rivers”

    If you want to find life, follow the rivers. Rivers are highly conducive to life because they sweep sediment and minerals across surfaces and into seas. So the discovery of ancient rivers on Mars is always exciting. And we’re not talking about just a few because a Penn State study has branded Mars as a “planet of rivers.”

    The study included satellite data, images from the Curiosity rover, and 3D scans from down here on Earth. Altogether, these data suggest that common crater formations called bench-and-nose landscapes are the remains of ancient riverbeds.

    Beforehand, these formations had not been associated with riparian causes, revealing that Mars was even wetter than previously hoped. With all its ancient (and current) water, every discovery seems to make it likelier that Mars was, or is, inhabited by at least some teeny-tiny things.[9]

    1 Mars May Have Been Like Yellowstone

    Yellowstone, America’s first national park, has rightfully gained global fame for its many diverse natural wonders. Especially its prismatic hot springs, which steam and bubble with multicolored activity.

    But like those Maybelline commercials from the 90s, the springs weren’t born this fabulous. Instead, the colors develop and reflect the microbial communities currently living in these environs. Excitingly, it’s possible that similar communities existed on Mars billions of years ago when our red planetary sibling planet harbored hot springs of its own.

    This potential life arose from destruction. Mars has been well-hit by comets and asteroids over its long career, and it took an especially brutal beating all those years ago. The biggest impacts (hundreds of miles across) from the ancient barrage created such intense heat that it could have turned the craters into hydrothermal springs.

    What’s so special about springs? They provide nutrients, like the sulfur that keeps microbes alive (and smelly) at Yellowstone. On Mars, they could have offered a window of millions of years for some kind of life to take hold.[10]

  • ‘The Handmaid’s Tale’ Had to Plan Character Deaths Very Strategically

    ‘The Handmaid’s Tale’ Had to Plan Character Deaths Very Strategically

     

    With just one episode to go in The Handmaid’s Tale, the creators, cast, and crew look back in a detailed new oral history that addresses some of the biggest questions viewers have asked about its story over the years. That includes: if Gilead is such a violent police state fond of swiftly executing any and all dissidents, how has Elisabeth Moss’ character, the rebellion-leading June Osborne, managed to survive for six seasons?

    This week’s “Execution” saw June literally escaping a hangman’s noose—just her latest miracle after dodging bullets, being run over by a truck, and several other very near misses. (A few characters did meet their ends elsewhere in the episode.) Speaking to the Hollywood Reporter, The Handmaid’s Tale novel author Margaret Atwood admitted that was a necessary element in a story that may be inspired by reality, but is obviously fictional.

    “About the only thing that would be different from real life is that had June got caught, she would have been shot,” Atwood said. “But you can’t do that because you can’t eliminate your central character. She’s still there because, as there always have been, there are collaborators on the inside helping her. Our rule for the show was: ‘Nothing that you put in can be pure invention. You always have to tell me when this happened in history.’ There’s almost nothing you can make up in this area that hasn’t happened somewhere.”

    Keeping the main character alive is one thing, but The Handmaid’s Tale also had to take Atwood’s sequel novel, The Testaments—released in 2019, and set 15 years after her 1985 original—into consideration, especially after Hulu announced it would be adapting it as a Handmaid’s follow-up.

    “She gave me a very small no-kill list,” series creator Bruce Miller told THR, and it included Ann Dowd’s Aunt Lydia—a villain in early seasons who has finally (finally!) started to realize the true evil of Gilead as The Handmaid’s Tale nears its end.

    “I wonder if Bruce ever wanted to knock Lydia off! I just adore Margaret Atwood,” Dowd said to THR. “I’m very happy to have it continue because I really do love Lydia. Having the experience of starting already on The Testaments, the way Margaret wrote it just makes so much sense and the writers have captured it beautifully. It’s a very good step from the end of Handmaid’s to the beginning of the Testaments.”

    Added Miller, “Lydia is a fucking cat. She has 900 lives, which is exactly how those people survived in those kinds of regimes—they’re very good at stepping slightly out of the way when the shit starts to fall.”

    Another character who lived longer than anyone expected? Joseph Fiennes’ Commander Waterford, who was originally only going to stick around for a season or two. (He did eventually meet a brutal-for-him, satisfying-for-viewers demise in season four.)

    “Joe’s the most lovely guy and [Waterford is] a despicable character and it’s no fun playing a despicable character when you’re a lovely guy, so I was encouraging him to stick with it,” Miller recalled. “Because June and Serena [Waterford, Fred’s wife played by Yvonne Strahovski) had such an interesting relationship, Fred became much more than just this sleazy, blowhardy pervert in the story.”

     

  • This Injectable Ink Lets Doctors 3D Print Tissues Inside the Body Using Only Ultrasound

    This Injectable Ink Lets Doctors 3D Print Tissues Inside the Body Using Only Ultrasound

    What if doctors could treat deep injuries or repair tissues without making a single cut on your body? It may sound impossible, but a team of researchers from the California Institute of Technology (Caltech) just showed this is achievable.

    Without any surgery or stitches, they 3D printed tissues inside disease-affected areas of a mouse’s bladder and a rabbit’s leg muscles using a special injectable bioink. What’s interesting about the bioink is that it stays liquid at body temperature, but when exposed to ultrasound, it begins forming desirable shapes and solidifies.

    This novel method is called deep tissue in vivo sound printing (DISP), and in the future, it could be used to deliver drugs and repair (or replace) damaged cells, tissues, and organs in humans.

    The researchers suggest that DISP could take healthcare to the next level by making treatments faster, less invasive, and even possible in places where surgery isn’t an option, like on the battlefield or in remote locations.

    “We validated DISP by successfully printing near diseased areas in the mouse bladder and deep within rabbit leg muscles in vivo, demonstrating its potential for localized drug delivery and tissue replacement. DISP’s ability to print conductive, drug-loaded, cell-laden, and bioadhesive biomaterials demonstrates its versatility for diverse biomedical applications,” the researchers note.

    How does DISP work?

    Credit: Elham Davoodi et al/Science/AAA.

    The key to DISP’s effectiveness lies in its bioink. This bioink contains long-chain polymers and special chemicals known as crosslinkers, which help the polymers stick together and form a gel.

    However, to keep the ink from turning solid too early, the crosslinkers are safely sealed inside tiny, heat-sensitive capsules called liposomes.

    These liposomes are designed such that they burst only when they are warmed to just a few degrees above body temperature. Once the bioink is injected into the body, a focused ultrasound beam is used to heat a specific area. This causes the liposomes at that location to open and release the crosslinkers, which then react with the polymers to form a solid gel-like structure right there in the tissue.

    To test this idea, the researchers also carried out experiments on rabbits, mice, and lab-grown cancer cells. In rabbits, they successfully printed artificial tissue structures four centimeters beneath the skin to patch wounds or repair internal damage. The team further tested whether DISP could be used to deliver cancer drugs more precisely.

    The 3D printed structures created using DISP. Image credits: Elham Davoodi and Wei Gao

    They prepared a version of the bioink that contained doxorubicin, a widely used chemotherapy medication, and applied it to cells with bladder cancer. Using ultrasound, they solidified the drug-containing gel exactly where the cancer cells were located. This setup allowed the drug to be released gradually over several days, leading to much effective cancer cell death than when doxorubicin was injected all at once.

    In additional experiments, the researchers added materials like carbon nanotubes and silver nanowires to the bioink. These made the printed gels electrically conductive, which could be useful in the future for building implantable sensors that track temperature, muscle activity, or heart signals from inside the body.

    “Importantly, no toxicity from the hydrogel was detected, and leftover liquid bioink is naturally flushed from the body (of animals) within seven days,” the study author said.

    Sound is better than light

    What makes DISP more promising than previous methods is its ability to reach deep into the body. Earlier techniques used light, such as infrared, to perform similar tasks, but light cannot travel far beneath the skin. Ultrasound, on the other hand, is already used in medical imaging for its deep penetration and safety.

    “Infrared penetration is very limited. It only reaches right below the skin. Our new technique reaches the deep tissue and can print a variety of materials for a broad range of applications, all while maintaining excellent biocompatibility,” Wei Gao, one of the study authors and a biomedical engineer at Caltech, said.

    However, the results are still early and limited to animals and lab models. The next steps would be to test DISP in larger animals and, eventually, in humans.

    Also, “in the future, with the help of AI, we would like to be able to autonomously trigger high-precision printing within a moving organ such as a beating heart,” Gao added.

    The study is published in the journal Science.

  • Common Cold Sore Virus May Mess With Your Brain Decades Later (and Cause Alzheimer’s)

    Common Cold Sore Virus May Mess With Your Brain Decades Later (and Cause Alzheimer’s)

    The Herpes simplex virus hides in plain sight. For most, it’s a fleeting nuisance — a tingling lip, a blister, a cold sore. But new research suggests that herpes simplex virus type 1 (HSV-1), carried silently by billions, may leave a far more lasting imprint deep within the brain: an increased risk of Alzheimer’s disease.

    A growing faction of scientists suspects that Alzheimer’s may not begin in the brain, but rather with the body’s reaction to something far more common — infection. A new study highlights HSV-1, the common Herpes simplex virus, as one of the prime suspects.

    Viruses and the brain

    Alzheimer’s is one of the most horrifying diseases out there. It’s a slow-burning catastrophe. It devours memories, burdens families, and steals away patients’ sense of self. Alzheimer’s disease affects over 55 million people worldwide and is the leading cause of dementia, accounting for 60–80% of cases. With aging populations, the global burden is expected to triple by 2050, straining healthcare systems and families alike.

    It’s also a costly disease. In the US alone, it costs over $305 billion a year. Most research has focused on the brain’s internal failings — those toxic amyloid-beta plaques and tau tangles that choke neurons over time.

    The new study, led by researchers from Gilead Sciences and the University of Washington, crunched insurance claims data from over 344,000 people diagnosed with Alzheimer’s and an equal number of matched controls. Their question was simple: Were HSV-1 infections more common in those who developed Alzheimer’s?

    The answer, apparently, is also simple: yes. Alarmingly, people who had HSV-1 infections were far more likely (80%) to develop Alzheimer’s.

    The association goes even deeper. Those who took antiviral drugs after their HSV-1 diagnosis were 17% less likely to get Alzheimer’s compared to their HSV-1-infected peers who didn’t get treatment.

    “This is a well-conducted study adding to strong data in the field linking HSV-1 and other viral infections to increased risk of developing Alzheimer’s disease, but it is important to note that HSV-1 infection, which is extremely common in the population, is by no means a guarantee that someone will develop Alzheimer’s,” says Tara Spires-Jones, Director of the Centre for Discovery Brain Sciences at the University of Edinburgh, who was not involved in the study.

    What the numbers are really saying

    On its face, an 80% increased risk sounds terrifying. But you have to keep in mind that this is relative risk. About 1 in 9 people age 65 and older (11%) has Alzheimer’s. So, an 80% increase on that takes it to 19.8%.

    But it also gets a bit stranger. Out of 344,628 Alzheimer’s patients in the dataset, just 1,507 — about 0.44% — had a recorded HSV-1 diagnosis. That’s still far below the estimated prevalence of HSV-1 in the general population. So, what gives?

    Most people with HSV-1 never get formally diagnosed. They don’t see a doctor for it, and if they do, it might not be recorded properly in an insurance database.

    “Despite the large sample size, this research has limitations partly due to only using health records and administrative claims data. Most people infected with HSV-1 don’t have any symptoms so some infections might not have been recorded. Infections predating the information recorded are also not available. Although cases were matched with controls, diagnosing Alzheimer’s disease, especially in the early stages, remains a challenge,” noted Dr. Sheona Scales, Director of Research at Alzheimer’s Research UK, who wasn’t involved in the study. “This study doesn’t tell us if infections are causing the risk, it only shows an association.”

    In other words, we may be looking at the tip of an iceberg. Or we may be chasing a ghost. This study doesn’t definitively clarify the problem. However, the idea that viruses may be causing problems like Alzheimer’s is not new.

    Viral defenses gone wrong

    Back in 2010, researchers discovered that amyloid-beta — the protein long blamed for Alzheimer’s — also happens to have antimicrobial properties. It seems to be one of the brain’s ways of defending itself, forming plaques to trap invading microbes like HSV-1.

    The mechanism, in time, could become a liability. If repeated infections or reactivations of HSV-1 nudge the brain’s immune system into overdrive, this could slowly create the conditions for cognitive decline.

    “This is a well-conducted study adding to strong data in the field linking HSV-1 and other viral infections to increased risk of developing Alzheimer’s disease, but it is important to note that HSV-1 infection, which is extremely common in the population, is by no means a guarantee that someone will develop Alzheimer’s,” says Tara Spires-Jones, Director of the Centre for Discovery Brain Sciences at the University of Edinburgh.

    “Why viral infections may increase risk of dementia is not fully understood, but the most likely explanation is that infections increase inflammation in the body and contribute to age-related brain inflammation.  More research is needed to understand the best way to protect our brains from Alzheimer’s disease as we age, including a better understanding of links between viral infection and Alzheimer’s risk.”

    There’s also another theory that genetics plays a role. In particular, the ApoE-ε4 gene could play a role. This gene is a known risk factor for Alzheimer’s, and it is also linked with more severe HSV-1 outbreaks. The virus, it seems, might hit their brains harder, or linger longer.

    Some scientists are skeptical

    Not everyone is convinced that these findings are ready for prime time. Dr. David Vickers from the University of Calgary didn’t mince words: “This pharma-funded research exaggerates the role of HSV-1, failing to appreciate its absence in 99.56% of Alzheimer’s cases. The observed 17% hazard reduction with antiherpetic drugs translates to a mere nine-month delay in AD onset, offering no meaningful relief to the US$305 billion costs for treatment.”

    It’s a fair critique. The study was funded by Gilead Sciences, which manufactures antiviral drugs. And observational studies based on insurance data come with baggage: misdiagnoses, inconsistent record-keeping, and the fact that correlation isn’t causation.

    Still, others argue the findings are too consistent — and too important — to ignore.

    “Smaller but significant effects are also seen for HSV-2 and varicella zoster virus (VZV). With many GPs and the population being unaware of the dementia related benefits of treating HSV infections and preventing VZV activation through vaccination, it is time to call for actions informing those working in primary care as well as the population at large,” adds Cornelia van Duijn, Professor of Epidemiology at the Nuffield Department of Population Health, University of Oxford.

    So where does this all leave us?

    This study won’t be the last word on the issue. There’s much we don’t know. But it moves the conversation in a compelling direction. There’s an increasing amount of evidence that suggests our body’s response to certain viruses could put us at an increased risk of developing Alzheimer’s disease in later life. It’s not a clear risk factor for now, but it’s definitely something worth exploring more.

    Future research needs to answer the big questions. Do antivirals work long-term? Should they be given preventively to people at genetic risk? Could vaccines against HSV-1 reduce Alzheimer’s cases? And how exactly do viruses interact with the aging brain?

    That said, the stakes are enormous. Even a modest delay in the onset of Alzheimer’s — say, one or two years — could have huge public health benefits if applied across millions of people.

    In the meantime, if you’re carrying an infection, you’re probably best off trying to treat it properly. Research is increasingly showing that infections just cause acute illness — they can leave behind long-term damage. Chronic hepatitis can lead to liver cancer. HPV infections can trigger cervical cancer. Even seemingly minor bugs like Helicobacter pylori can inflame the stomach lining and increase the risk of ulcers and gastric cancer.

    Infections are not always fleeting; sometimes, they lay the groundwork for diseases that emerge years or even decades later.

    The study was published in the British Medical Journal.

  • This Startup Is Using Ancient DNA to Recreate Perfumes from Extinct Flowers

    This Startup Is Using Ancient DNA to Recreate Perfumes from Extinct Flowers


    Photo courtesy of Future Society

    In a glass vial in Boston, a vanished world blooms again.

    Its contents, light and fragrant, are nothing more than a few molecules suspended in alcohol. But inhale — and for a fleeting moment, the past returns. The crisp scent of a long-lost Indian flower. The sweetness of a Hawaiian hibiscus that vanished over a century ago. The grassy hush of an extinct American prairie.

    These scents, now bottled by a new biotech perfume brand called Future Society, never touched the noses of anyone alive today — until now. They are the reconstructed fragrances of extinct flowers, revived from dried herbarium specimens through DNA sequencing, synthetic biology, and the work of master perfumers.

    And they are not just perfumes. They are, as the company puts it, “scent-surrections.”

    From Herbarium to Atomizer

    Credit: Harvard University.

    The project began, as many ambitious ideas do, with a simple question: What if we could smell the past?

    At Harvard’s Herbarium, more than five million specimens of algae, fungi, and plants rest in cabinets that stretch back generations. In 2016, Christina Agapakis, a synthetic biologist and creative director at the Boston biotech firm Ginkgo Bioworks, began taking samples from several extinct flowers — some last seen over 100 years ago. Among them was Hibiscadelphus wilderianus, a Hawaiian hibiscus-relative last recorded in 1912 before ranching and deforestation wiped it from the southern slopes of Maui.

    Scientists extracted DNA from these dried blossoms, searching for the genes responsible for the enzymes that create scent molecules — nature’s aromatic calling cards used to attract pollinators. These genes were then synthesized and inserted into yeast cells, which began to churn out the same or very similar scent molecules.

    Of course, that doesn’t mean that these perfumes smell exactly like their extinct flowers they’re supposed to mimic. For one, it would be impossible to know for sure. And secondly, flowers are darn complex.

    Future society extinct flower Haunted Rose perfume bottle
    Photo courtesy of Future Society
    Future society extinct flower Solar Canopy perfume bottle
    Photo courtesy of Future Society

    Part Science, Part Storytelling

    “We’re never actually going to know what these flowers smelled like,” said Jasmina Aganovic, the MIT-trained founder of Future Society. “This is just a starting piece of data . . . It’s not going to be able to tell us everything, but maybe one day it will.”

    Instead of seeking total scent accuracy, Aganovic and her collaborators embraced interpretation. Working with renowned perfumers, they transformed genetic clues into olfactory stories.

    Six scents now make up Future Society’s debut line. Each is tied to a specific extinct plant — and each tells one of these stories.

    Floating Forest evokes the lush canopy of Shorea cuspidata, a towering Bornean tree lost to logging. Invisible Woods reimagines Wendlandia angustifolia, a delicate white-flowered tree from India’s Western Ghats, likely driven to extinction by drought. Grassland Opera is a musky, green tribute to Orbexilum stipulatum, a flower of the American plains, last seen in 1812.

    The process is part science, part storytelling, and part elegy. “With plants that are from another time, never before have we been able to time travel through smell,” said Aganovic. “But now we can do that, thanks specifically to DNA sequencing.”

    A New Use for Old Science

    According to neuroscientist Karina Del Punta, roughly 75% of daily emotions are shaped by smell. And unlike language or sight, scent bypasses our cultural filters, going straight to the brain’s emotional centers.

    “Reconstructed scents of extinct flowers are not just olfactory curiosities — they’re emotional bridges between what has been lost and what still might be saved,” Del Punta told Atmos. “They can transform extinction from an abstract concept into an intimate, embodied experience.”

    This emotional dimension is key to the project’s ambition: reframing climate grief as climate engagement. “We talk about the future as if it’s already destined to be apocalyptic,” said Aganovic. “But the future hasn’t been written.”

    Instead of glamorizing extinction, Future Society’s fragrances attempt to honor what’s gone — and build momentum for what can still be protected. “We can’t bring the flowers back. We can’t science our way out of all of our problems,” said Aganovic. “But we can think about how science enables us to do things that we weren’t able to before.”

    Reinventing Sustainability Through Biotechnology

    Future Society’s fragrances are also a proof-of-concept for something bigger: the power of biotech to revolutionize sustainable product design.

    Traditional perfume production relies on vast fields of flowers, thousands of which are stripped from the soil to make just a kilo of oil. In contrast, the biotech approach uses yeast to produce scent molecules with pinpoint precision — no farming, no fertilizers, and far less waste.

    “Through advances like DNA sequencing, we now have access to nature’s instruction manual,” said Aganovic. “That means we no longer need to extract plants from the Earth or disrupt nature.”

    This vision is shared by Ginkgo Bioworks. Ginkgo’s co-founder Jason Kelly first proposed reviving the smell of an extinct flower nearly a decade ago.

    What began as a speculative project blossomed into an immersive art installation called Resurrecting the Sublime, developed with artist Alexandra Daisy Ginsberg and scent expert Sissel Tolaas. The experience used scent diffusion and soundscape to ask not just what a flower once smelled like — but how it made the world feel.

    Now, that same spirit lives on your skin.

    Between Jurassic Park and Chanel No. 5

    Despite the comparisons to Jurassic Park, Aganovic is careful to draw a line. These aren’t cloned, resurrected plants. They’re artistic reimaginings, rooted in data but elevated by emotion.

    Each Future Society scent is an act of speculative reconstruction, similar to how paleoartists render extinct creatures from fossils and guesswork. “The science is the inspiration and starting point, but artistic interpretation can take this in whatever direction,” Aganovic told Forbes. “This is not how creative briefs are developed — they had never seen one like this.”

    In doing so, the brand redefines both what perfume can be and what science can do. “How we talk about science is a little bit different,” Aganovic added. “I have come to view science as craftsmanship.”

    And in that craftsmanship, she sees a way forward — not just for fragrance, but for our collective imagination.

    “What is actually going to rise to the occasion of the industry, and the best version of the future that we want to see?” she asked. “We’re using science as a creative tool, rather than a performance driver.”

  • Where Else in the Solar System Could Life Potentially Exist?

    Where Else in the Solar System Could Life Potentially Exist?

    Our planet is absolutely lousy with life. A teaspoon of soil from your yard can contain up to 1 billion bacteria. Under a square meter of soil may have 200,000 insects. The same space can have 10 million nematodes. Even though only about 1.2 million species have been identified, it’s estimated that there are probably closer to 8.75 million species living on Earth

    Some estimates, which include microbes, have suggested there may be 1 trillion life forms on Earth. And if you wanted to guess individual life forms? A single human body is home to over 100 trillion bacteria. The whole planet may house a nonillion bacteria. That’s a one with 30 zeros.  The point is, there’s a lot of life on earth. 

    Our planet is covered in life, more of it than you could ever imagine. How is this the only place that has life? Many of us are open to the idea that there could be life elsewhere, we just haven’t found it yet. But, without in mind, where exactly might this other life live? We don’t need to travel the vast reaches of space to start guessing. Why don’t we check our own solar system and see what it has to offer? There are more possibilities than you might realize. 

    Our solar system has 8 planets with 293 confirmed moons amongst them, plus five dwarf planets with a few moons as well. That’s over 300 potential places for life!

    The Clouds of Venus 

    Remember the first time you saw Cloud City in Star Wars? Didn’t it look cool and kind of peaceful? Who wouldn’t want to live in the clouds? The idea of being in the clouds on an alien world isn’t as far-fetched as it seems because there has been speculation about the potential for life in the clouds of Venus.

    Venus averages around  870° F or 465° C, making it extremely inhospitable to life as we know it. It also has 2000 times the amount of CO2 in the atmosphere as Earth and rains acid. It’s unpleasant. But there are clouds. 

    Though the atmosphere is dense and it takes 243 of our days for one day on Venus to pass, there has been speculation that microbial life could live in its thick cloud cover. The clouds offer some small amounts of water and sunlight, and there may be nutrients, at least the kind for bacteria, in there.  Things like carbon, hydrogen, nitrogen, phosphorus, and sulfur are present in trace amounts, but enough that microbial life could exist. Organisms that have metabolisms centered on iron or sulfur may be right at home there. 

    Spectral analysis of the cloud cover on Venus shows inexplicable dark patches. It has been theorized that these places, where sunlight is being absorbed more heavily than others, may be home to bacteria that are thriving in the light on these nutrients.

    More significant is that scientists have detected phosphine gas. This gas is produced by living things and while it doesn’t prove life exists, it’s a strong indicator that it may exist. It’s been suggested that if you found phosphine on a typical, rocky planet the only reason it would be there would be that life is present. Those who investigated it on Venus have been unable to account for the gas except as a byproduct of life.

    Jupiter’s Moon Europa

    The largest planet in our solar system, Jupiter, has 95 moons to choose from if you’re looking for a new place to live. Europa is one of the most likely candidates for sustaining life, though. Maybe not your life, but some life. 

    Europa is mostly ice, but it does have oceans under that ice.  It’s believed that, although very salty, Europa has twice as much water as all the oceans on Earth. If there is a rocky seabed under these Europan oceans, they may have hydrothermal vents that produce nutrients that could sustain life, just like in the gas clouds of Venus.

    The surface of Europa is remarkably smooth compared to every other body in our solar system. Because it’s completely covered in ice that is about 10 to 15 miles thick, there is very little change in the geography. However, there are places where cracks, fissures, and other features in the landscape indicate that maybe warmer ice has surfaced from below in the past, or liquid water flows far below.

    In 2024, NASA launched the Clipper spacecraft towards Europa. It will get there in 2030, and then we’ll have some idea what’s going on under the surface of the ice. The tools that the Clipper is carrying with it should be able to determine whether or not the building blocks of life are present on Europa, and it might also be able to detect life itself. Or maybe not. It’s not technically designed to find life. We’ll have to wait and see what happens!

    Saturn’s Enceladus

    Just like Jupiter, Saturn has some ocean moons as well. Enceladus is the one that we’re most interested in when it comes to the search for potential life in the universe. The moon is incredibly small, only 314 miles in diameter compared to Earth’s nearly 8,000 miles and Saturn’s nearly 75,000 miles. But Enceladus does have an icy surface under which sits an ocean that covers the entire moon

    At the South Pole of the moon, a geyser expels ice and gas into space. The Cassini spacecraft was able to analyze some of the ice and determine it’s full of salt, like our oceans. Elements crucial for life, including carbon, hydrogen, phosphorus, nitrogen, and sulfur, are all there.  It is warmed by tidal heating. That means the moon has water, energy, and chemistry. Enceladus has all three.

    One of the chemicals discovered by Cassini in the geyser is hydrogen cyanide.  Even though by itself hydrogen cyanide is poisonous, it’s also a chemical precursor to the formation of amino acids and DNA, the basic building blocks of life. In addition, compounds like methane, propylene, ethane, and acetylene were discovered and these are all organic molecules that are important to the formation of life. 

    Saturn’s Titan

    The moon Titan was not named by accident. It has a diameter of about 2,500 miles, making it about 40% of the size of Earth and larger than the planet Mercury. It’s also the only other place in our entire solar system, besides Earth, that has standing liquid on the surface in the form of lakes and rivers. Also like Earth, and unlike anywhere else, it’s the only place with a cycle of rain that fills those lakes and rivers, evaporates, and rains down again.

    Granted, the rain on Titan isn’t super refreshing and is mostly liquid methane, but it’s still rain. The thick atmosphere of nitrogen means the rain there falls about 5 times slower than it does on Earth, as well. Plus, at temperatures around -179° C, it’d be a frosty rain when it finally.

    Titan is much less hospitable for life than Earth, but the possibility exists that some kind of life, far different from ours, could have evolved there. Life would have had to adapt to methane rather than water. Also, while life here requires a lipid cell membrane, life there would have to exist without the need for cell membranes as we understand them. 

    The methane and ethane on Titan are all organic compounds. When sunlight hits methane, it breaks it down into more organic compounds. Here on Earth, we get new methane from living things. As life decays, it produces methane. But Titan is full of methane, so there’s some question about where it all comes from since, on Earth, it comes from life. That’s not to say we think there are massive numbers of hidden life forms there, but there’s more going on under the surface than we know.

    Jupiter’s Ganymede

    The biggest moon in the solar system is Jupiter’s Ganymede. It’s about two-fifths the size of the Earth. We know there is an ocean on Ganymede that contains more water than all the water on Earth, about 100 miles below the surface, and we know that it has its own magnetic field, something that usually only happens on planets. 

    Deep down inside, Ganymede has a molten metal core, just like here on Earth. And with water below the ice, water that may extend all the way or be layered with ice all the way down to the core, there’s a chance that warm oceans are teeming with the chemicals needed to support life. So, again, we have water, we have energy, and we have chemistry for life. Maybe. 

    Dwarf Planet Ceres

    Ceres is no moon; it’s a dwarf planet and one of five in our solar system, along with Pluto, Eris, Haumea, and Makemake. Ceres is found in an asteroid belt between Jupiter and Mars, making it the only dwarf in the inner solar system. And it also has the potential to be a life-sustaining environment thanks to the presence of water.

    The study of Ceres has led researchers to believe that the dwarf planet may have been hospitable to life at one time, even if it’s not any longer on the surface. There is evidence that long chains of hydrocarbons that can turn into fats, called long-chain aliphatic organics, may have bubbled to the surface in the past.

    The presence of these compounds has led researchers to believe that there may have been oceans on the surface of Ceres once upon a time that lasted for hundreds of millions of years. These compounds only last for around 10 million years, which means they are more recent than Ceres’ missing oceans. And that means the dwarf may still have oceans hidden beneath the surface with organic compounds that could potentially lead to life.

    Neptune’s Triton

    Neptune’s moon Triton is a place we have not studied very closely. The Voyager 2 spacecraft went past Triton in 1989 and took some pictures, but so far, that’s the only craft we sent out that far. It’s a frosty place with a surface temperature of – 235° C.  It’s covered in nitrogen ice, but there are some rocky formations, and it’s believed that inside is rock and metal. 

    The moon also demonstrates volcanic activity, and it has a thin atmosphere of nitrogen and methane. Methane, you’ll remember, is one of those compounds that we look for when we’re searching for life.

    Since Triton has active geysers, it may have liquid oceans beneath the icy surface. And volcanic activity means energy, and methane means chemistry, so again, we’re finding the components for potential life. 

    There is speculation that the energy needed to maintain a liquid ocean on Triton comes from the fact that the moon experiences Seasons. Because it dips above and below Neptune’s equator in its orbit, it faces the sun and will warm and cool at the poles, while Neptune’s gravity causes changes in the ocean it is believed may exist below the surface. That energy could provide all the pieces for life to form.

    Saturn’s Mimas

    Mimas is not one of the more well-known moons out in the solar system, but it holds some intriguing possibilities. It also looks a lot like the Death Star, which is unrelated but cool, nonetheless. 

    For years, this moon was overlooked because it appeared to be a cratered, dead rock of a place. But now there is evidence that it has an ocean, and it may be a young one. By young, we mean under 25 million years old and potentially just two million years old. This relatively young age could explain why no one thought it had an ocean before, because, buried under the ice, it hasn’t had the time to alter the surface geography the way oceans on the other moons and planets have.

    More recent data from the Cassini probe has led scientists to believe that the irregularities in Mimas’ orbit confirm that it must have a hidden ocean beneath the surface. Based on the data, half of Mimas’ volume may be liquid water. And just as with the other moons, if there is water, there’s a chance for organics and energy to provide the building blocks for life.

    Of course we have not definitively found life anywhere in the solar system just yet, but the information about Mimas, and all the moons, dwarf planets, in other worlds motivate to keep exploring, to look deeper, and to send more exploratory missions to find out if we are truly alone in our own solar system.

    The life we find will probably only be microbial, seemingly insignificant, but if we can determine that life formed independently more than once in the same solar system, the implication for the galaxy, in the universe at large, could be staggering.

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  • Sweden Passes Controversial Law Targeting OnlyFans: Users Could Face Prison Time Starting July 1

    Sweden Passes Controversial Law Targeting OnlyFans: Users Could Face Prison Time Starting July 1

    A new law passed by Sweden’s parliament is set to criminalize the purchase of online sex acts, including custom live shows on platforms like OnlyFans, placing digital sex buyers at risk of prison time. The legislation, which will come into effect on July 1, equates paying for remote sexual performances with soliciting in-person prostitution.

    According to Swedish MP Teresa Carvalho, the move aims to modernize sex purchase laws for the digital age: “This is a new form of sex purchase, and it’s high time we modernize the legislation to include digital platforms,” she said following the bill’s approval.

    Under the law, it will be illegal to pay for live, specially-commissioned sex acts performed on camera. Those found guilty of purchasing such services could face up to one year in prison, aligning with Sweden’s existing penalties for in-person sex buying.

    Importantly, pre-recorded adult content will remain legal to access and purchase.

    Though the bill has raised concerns about its impact on adult content creators, lawmakers insist it is not designed to punish sex workers. Carvalho argued the law’s true intent is to protect vulnerable individuals from exploitation, citing ties between digital sex trafficking, grooming, drug abuse, and human trafficking.

    Sweden LawSweden Law

    The legislation mirrors the controversial SESTA/FOSTA acts passed in the United States in 2018, which made platforms liable for enabling sex work. Yigit Adin, an activist at the European Sex Workers’ Rights Alliance, compared the Swedish law to that US precedent, warning it could similarly stifle online safety and income for adult creators.

    Despite cross-party support in Sweden’s parliament, critics say the bill doesn’t go far enough. Social Democrat politician Annika Strandhäll has called for a complete ban on platforms like OnlyFans, describing them as digital spaces where prostitution can flourish undetected.

    “Prostitution or the sex trade is constantly taking new forms, and it is important that politicians and legislators keep up,” Strandhäll told Swedish outlet Expressen. She also pushed for age verification systems on porn sites, warning about the ease with which children can currently access violent adult content.

    Sweden’s current sex work laws already criminalize buying sex but not selling it—a model often referred to as the “Nordic Model.” Pimps and traffickers face up to four years in prison.

    This latest expansion into the digital realm signals Sweden’s intent to further clamp down on the online sex trade, even as it ignites debate about privacy, platform accountability, and the rights of sex workers operating in digital spaces.

  • 5 Strange Cases Of People Who Lost Winning Lottery Tickets & Scratchcards

    5 Strange Cases Of People Who Lost Winning Lottery Tickets & Scratchcards

    Realising you’ve won a lottery prize can be an exhilarating experience. Elation, however, can soon turn to despair when you cannot locate the winning ticket or scratchcard.

    In these instances, people search everywhere in an attempt to find the piece of card or paper that proves they have won a prize.

    Some are lucky enough to find their winning ticket, whereas others are not. In this article, researched by Chief Gambler, here’s a look at the strangest ways people have lost their winning lottery tickets and scratchcards.

    1. Dog Eats Man’s Scratchcard For Lunch

    Gareth Thomas was ‘buzzing’ when he discovered he’d won £500 on a scratchcard he’d purchased in his home city of Cardiff, UK.

    But after leaving the scratchcard on the table at his house to bring in some washing from the garden, he returned five minutes later to discover it had been destroyed by his dog, Teddy, who obviously viewed it as a tasty snack.

    Gareth said: “Typical, isn’t it? The one time I actually win something, and the dog thinks it’s lunch.”

    Despite contacting the National Lottery in a vain attempt to claim his prize, Gareth was told that without a legible ticket, he would not receive the £500 winnings.

    2. Lucky Glove Compartment Discovery

    Thankfully, not all of these cases of lost or destroyed lottery tickets and scratchcards have an unhappy ending.

    Taxi driver, Amo Riselli from Gloucester, UK, left his winning lottery ticket in the glove compartment of his car for two days before finding it to realise he had matched five numbers, enough to scoop a huge £24,501,283.

    The cabbie declared he would retire with the winnings and buy his dream car, a Ferrari.

    3. Ticket Left In Pocket Of Donated Jacket

    Mildred Simoneriluto from Pennsylvania, US, was delighted when her lucky numbers came up in a lottery draw with a $2.5 million jackpot.

    Delight soon turned to despair for Mildred, though, when she realised she’d left the ticket in a pocket of a jacket she’d recently donated to a charity for veterans.

    When she contacted the charity, she was told that clothing donations are sent throughout the country and often around the world, meaning her winning ticket could be anywhere.

    4. $26m Fortune Washed Away

    A woman, who has not been named, says she destroyed her winning California Lottery ticket, and with it the chance of claiming the $26 million prize, by leaving it in her trouser pocket before putting them in the wash.

    Despite there reportedly being CCTV footage of the woman purchasing the ticket from a store, the California Lottery refused to pay out, with a spokeswoman saying “compelling substantial proof you were in possession of the ticket” was required.

    5. £76m Winning Ticket Found In Visor

    Well, as it’s only right to end on a happy note, here’s the story of Andrew Clarke, a builder from the UK, who managed to win a whopping £76m on the Euromillions after finding his ticket… eventually.

    After hearing about the unclaimed prize on the news, Andrew’s partner and niece encouraged him to check his tickets.

    Thankfully, he managed to find the winning ticket in the visor of his van, a whole six weeks after the draw had been made.